A Multidisciplinary Investigation to Determine the Structure and Source of Dimeric Impurities in AMG 517 Drug Substance
Figure 4
Aromatic region of the , -2D
HSQC spectrum of the enriched impurity fraction ((a) 600 MHz) and the , -2D
HMQC spectrum of AMG 517 ((b) 400 MHz) in DMSO-d6. In (a), numbers
designated as prime (e.g., ) represent signals of Unknown 1, with all
others representing signals of Unknown 2.
