A Multidisciplinary Investigation to Determine the Structure and Source of Dimeric Impurities in AMG 517 Drug Substance

<table>UV chromatogram from the LC-MS analysis of
the acid hydrolyzed impurities.  Labeled
peaks correspond to hydrolysis fragments of Unknown 1 (U1) and Unknown 2 (U2).</table>

International Journal of Analytical Chemistry

fig5

Figure 5

Figure 5: A Multidisciplinary Investigation to Determine the Structure and Source of Dimeric Impurities in AMG 517 Drug Substance 