International Journal of Analytical Chemistry / 2009 / Article / Tab 1

Research Article

A Multidisciplinary Investigation to Determine the Structure and Source of Dimeric Impurities in AMG 517 Drug Substance

Table 1

Gradient conditions used for the HPLC-UV and LC-MS analyses of AMG 517 and N-acetyl benzothiazole.

CompoundAMG 517N-acetyl Benzothiazole
(HPLC-UV and LC-MS)(HPLC-UV)(LC-MS)

Gradient programTime (min)%BTime (min)%BTime (min)%B
050505
156510301030
207015501550
279820752075
30982595

Flow rate1.0 mL/min1.5 mL/min1.0 mL/min

Sample diluent50% ACN/50% water10% ACN/90% water

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