Sensitive Spectrophotometric Method for Quantitation of Guaifenesin and Dropropizine in Their Dosage Forms

Table 1

Selected spectral data for the determination of guaifenesin and dropropizine by the proposed colorimetric method.

Parameters	GF	DR
Linearity range (𝜇g mL^−1)	5–45	10–80
Slope ± S.E	0.021±3.7E-04	0.011±1.77E-04
Intercept ± S.E.	0.014±0.0109	0.039±0.0089
Correlation coefficient	0.998	0.998
Accuracy ± S.D. precision	100.58±0.48	100.22±1.36
Injection repeatability (𝑛=15)	0.80–1.26	0.14–0.38
Assay reproducibility intraday (𝑛=9)	Muclear	Tussapine
	0.40%–1.79%	0.13%–0.28%
Interday (𝑛=27)	Muclear	Tussapine
	1.01%–1.72%	0.39%–0.73%
LOQ^a (𝜇g mL^−1)	4	7
LOD^a (𝜇g mL^−1)	2.5	4.5

aLOQ and LOD were done practically.