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International Journal of Analytical Chemistry
Volume 2011, Article ID 619310, 9 pages
http://dx.doi.org/10.1155/2011/619310
Research Article

Sensitive and Selective Spectrophotometric Determination of Gabapentin in Capsules Using Two Nitrophenols as Chromogenic Agents

Department of Chemistry, University of Mysore, Manasagangotri, Mysore 570006, India

Received 25 January 2011; Accepted 20 April 2011

Academic Editor: Pavel Nesterenko

Copyright © 2011 Sameer A. M. Abdulrahman and Kanakapura Basavaiah. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. J. O. Maryadele, An Encyclopedia of Chemicals, Drugs, and Biologicals. The Merck Index, Merck & Co., Inc., Whitehouse Station, NJ, USA, 14th edition, 2006.
  2. D. G. Themelis, P. D. Tzanavaras, and E. A. Boulimari, “Generic automated fluorimetric assay for the quality control of gamma aminobutyric acid-analogue anti-epileptic drugs using sequential injection,” Analytical Letters, vol. 43, no. 6, pp. 905–918, 2010. View at Publisher · View at Google Scholar · View at Scopus
  3. F. Belal, H. Abdine, A. Al-Majed, and N. Y. Khalil, “Spectrofluorimetric determination of vigabatrin and gabapentin in urine and dosage forms through derivatization with fluorescamine,” Journal of Pharmaceutical and Biomedical Analysis, vol. 27, no. 1-2, pp. 253–260, 2002. View at Publisher · View at Google Scholar · View at Scopus
  4. E. M. Hassan, F. Belal, O. A. Al-Deeb, and N. Y. Khalil, “Spectrofluorimetric determination of vigabatrin and gabapentin in dosage forms and spiked plasma samples through derivatization with 4-chloro-7-nitrobenzo-2-oxa-1,3-diazole,” Journal of AOAC International, vol. 84, no. 4, pp. 1017–1024, 2001. View at Google Scholar · View at Scopus
  5. M. Manera, M. Miró, M. F. T. Ribeiro et al., “Rapid chemiluminometric determination of gabapentin in pharmaceutical formulations exploiting pulsed-flow analysis,” Luminescence, vol. 24, no. 1, pp. 10–14, 2009. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  6. B. U. Rao, F. Maqdoom, and A. P. Nikalje, “Determination of gabapentin in bulk drug and in pharmaceutical dosage form by HPLC method,” Journal of the Chilean Chemical Society, vol. 54, no. 4, pp. 424–427, 2009. View at Google Scholar · View at Scopus
  7. R. S. Gujral and S. M. Haque, “A validated method without derivatization for the determination of gabapentin in bulk, pharmaceutical formulation and human urine samples,” International Journal of Biomedical Science, vol. 5, no. 2, pp. 169–174, 2009. View at Google Scholar · View at Scopus
  8. E. Souri, H. Jalalizadeh, and A. Shafiee, “Optimization of an HPLC method for determination of gabapentin in dosage forms through derivatization with 1-fluoro-2,4-dinitrobenzene,” Chemical and Pharmaceutical Bulletin, vol. 55, no. 10, pp. 1427–1430, 2007. View at Publisher · View at Google Scholar · View at Scopus
  9. R. S. Gujral and S. M. Haque, “Development and validation of a new HPLC method for the determination of gabapentin,” International Journal of Biomedical Science, vol. 5, no. 1, pp. 63–69, 2009. View at Google Scholar · View at Scopus
  10. A. B. Ciavarella, A. Gupta, V. A. Sayeed, M. A. Khan, and P. J. Faustino, “Development and application of a validated HPLC method for the determination of gabapentin and its major degradation impurity in drug products,” Journal of Pharmaceutical and Biomedical Analysis, vol. 43, no. 5, pp. 1647–1653, 2007. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  11. A. Gupta, A. B. Ciavarella, V. A. Sayeed, M. A. Khan, and P. J. Faustino, “Development and application of a validated HPLC method for the analysis of dissolution samples of gabapentin drug products,” Journal of Pharmaceutical and Biomedical Analysis, vol. 46, no. 1, pp. 181–186, 2008. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  12. F. M. Lin, H. S. Kou, S. M. Wu, S. H. Chen, and H. L. Wu, “Capillary electrophoresis analysis of gabapentin and vigabatrin in pharmaceutical preparations as ofloxacin derivatives,” Analytica Chimica Acta, vol. 523, no. 1, pp. 9–14, 2004. View at Publisher · View at Google Scholar · View at Scopus
  13. R. Sekar and S. Azhaguvel, “Indirect photometric assay determination of gabapentin in bulk drug and capsules by capillary electrophoresis,” Journal of Pharmaceutical and Biomedical Analysis, vol. 36, no. 3, pp. 663–667, 2004. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  14. F. Jalali, E. Arkan, and G. Bahrami, “Preparation of a gabapentin potentiometric sensor and its application to pharmaceutical analysis,” Sensors and Actuators, B, vol. 127, no. 1, pp. 304–309, 2007. View at Publisher · View at Google Scholar · View at Scopus
  15. R. N. Hegde, B. E. K. Swamy, N. P. Shetti, and S. T. Nandibewoor, “Electro-oxidation and determination of gabapentin at gold electrode,” Journal of Electroanalytical Chemistry, vol. 635, no. 1, pp. 51–57, 2009. View at Publisher · View at Google Scholar · View at Scopus
  16. H. E. Abdellatef and H. M. Khalil, “Colorimetric determination of gabapentin in pharmaceutical formulation,” Journal of Pharmaceutical and Biomedical Analysis, vol. 31, no. 1, pp. 209–214, 2003. View at Publisher · View at Google Scholar · View at Scopus
  17. J. Al-Zehouri, S. Al-Madi, and F. Belal, “Determination of the antiepileptics vigabatrin and gabapentin in dosage forms and biological fluids using Hantzsch reaction,” Arzneimittel-Forschung/Drug Research, vol. 51, no. 2, pp. 97–103, 2001. View at Google Scholar · View at Scopus
  18. H. Salem, “Analytical study for the charge-transfer complexes of gabapentin,” African Journal of Pharmacy and Pharmacology, vol. 2, no. 7, pp. 136–144, 2008. View at Google Scholar
  19. V. R. Galande, K. G. Baheti, and M. H. Dehghan, “UV-Vis spectrophotometric method for estimation of Gabapentin and Methylcobalamin in bulk and tablet,” International Journal of ChemTech Research, vol. 2, no. 1, pp. 695–699, 2010. View at Google Scholar · View at Scopus
  20. F. A. Siddiqui, M. S. Arayne, N. Sultana et al., “Spectrophotometric determination of gabapentin in pharmaceutical formulations using ninhydrin and π-acceptors,” European Journal of Medicinal Chemistry, vol. 45, no. 7, pp. 2761–2767, 2010. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  21. R. S. Gujral, S. M. Haque, and P. Shanker, “A sensitive UV spectrophotometric method for the determination of gabapentin,” E-Journal of Chemistry, vol. 6, supplement 1, pp. S163–S170, 2009. View at Google Scholar
  22. M. F. T. Ribeiro, J. L. M. Santos, and J. L. F. C. Lima, “Piezoelectric pumping in flow analysis: application to the spectrophotometric determination of gabapentin,” Analytica Chimica Acta, vol. 600, no. 1-2, pp. 14–20, 2007. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  23. F. A. El-Yazbi, A. A. Gazy, H. Mahgoub, M. A. El-Sayed, and R. M. Youssef, “Spectrophotometric and titrimetric determination of nizatidine in capsules,” Journal of Pharmaceutical and Biomedical Analysis, vol. 31, no. 5, pp. 1027–1034, 2003. View at Publisher · View at Google Scholar · View at Scopus
  24. M. H. Abdel-Hay, S. M. Sabry, M. H. Barary, and T. S. Belal, “Spectrophotometric Determination of Bisacodyl and Piribedil,” Analytical Letters, vol. 37, no. 2, pp. 247–262, 2004. View at Publisher · View at Google Scholar · View at Scopus
  25. M. Y. El-Mammli, “Spectrophotometric determination of flucloxacillin in pharmaceutical preparations using some nitrophenols as a complexing agent,” Spectrochimica Acta—Part A, vol. 59, no. 4, pp. 771–776, 2003. View at Publisher · View at Google Scholar · View at Scopus
  26. E. Regulska, M. Tarasiewicz, and H. Puzanowska-Tarasiewicz, “Extractive-spectrophotometric determination of some phenothiazines with dipicrylamine and picric acid,” Journal of Pharmaceutical and Biomedical Analysis, vol. 27, no. 1-2, pp. 335–340, 2002. View at Publisher · View at Google Scholar · View at Scopus
  27. T. Higuchi and E. Brochmann-Hanssen, Pharmaceutical Analysis, CBS Publishers, New Delhi, India, 1997.
  28. G. Saito and Y. Matsunaga, “Charge-transfer and proton-transfer in the formation of molecular complexes. I. The complex isomerization of some anilinium picrates by melting,” Bulletin of the Chemical Society of Japan, vol. 44, pp. 3328–3335, 1971. View at Google Scholar
  29. A. S. Amin, A. A. El-Fetouh Gouda, R. El-Sheikh, and F. Zahran, “Spectrophotometric determination of gatifloxacin in pure form and in pharmaceutical formulation,” Spectrochimica Acta—Part A, vol. 67, no. 5, pp. 1306–1312, 2007. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  30. M. S. Refat, L. A. El-Zayat, and O. Z. Yeşilel, “Spectroscopic characterization of charge-transfer complexes of morpholine with chloranilic and picric acids in organic media: crystal structure of bis(morpholinium 2,4,6-trinitrocyclohexanolate),” Spectrochimica Acta—Part A, vol. 75, no. 2, pp. 745–752, 2010. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  31. International Conference on Harmonization of Technical Requirements for Registration of Pharmaceuticals for Human Use, ICH Harmonisation Tripartite Guideline. Validation of Analytical Procedures: Text and Methodology Q2 (R 1), Complementary Guideline on Methodology, London, UK, November 1996.