Sensitive and Selective Spectrophotometric Determination of Gabapentin in Capsules Using Two Nitrophenols as Chromogenic Agents

Table 5

Method robustness and ruggedness.

Method	GBP Taken μg mL^−1	Robustness (%RSD)		Ruggedness (%RSD)
		Reagent volume	Reaction time	Interanalysts (𝑛=3)	Interinstruments (𝑛=3)
	5.00	1.48	0.76	0.58	2.58
Method A	7.50	1.26	0.85	0.63	1.74
	10.00	0.85	1.08	0.87	2.64
	8.00	0.68	1.18	0.75	3.03
Method B	12.00	1.12	1.26	1.09	2.86
	16.00	1.38	1.56	1.27	3.25

*In method A, the volume of PA was 0.8, 1.0 and 1.2 mL, and the reaction time was 8, 10, and 12 min. In method B, the volume of 2,4-DNP added was 0.65, 0.75, and 0.85 mL, and the reaction time was 8, 10, and 12 min.