Research Article
Application of Certain π-Acceptors for the Spectrophotometric Determination of Alendronate Sodium in Pharmaceutical Bulk and Dosage Forms
Table 1
Selected spectral data for the determination of alendronate sodium by proposed spectrophotometric methods.
| | Parameter | Values for
method A | Values for
method B |
| | (nm) | 840 | 465 | | Beer’s law verification range (μg mL−1) | 2–10 | 2–12 | | Molar absorptivity (L mole−1 cm−1) | 7.9 × 104 | 4.6 × 104 | | Sandell’s sensitivity (μg ml−1 per 0.001 A) | 4.0 × 10−3 | 4.9 × 10−3 | | Regression equation (Y*) | | | | Slope (b) | 0.0254 | 0.0351 | | Intercept (a) | 0.0238 | 0.0241 | | Correlation coefficient (r) | 0.9989 | 0.9997 | | Limit of detection (μg mL−1) | 0.19 | 0.30 | | Limit of quantification (μg mL−1) | 0.62 | 0.99 |
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Y*: a + bC, where C is the concentration of analyte (μg/mL) and Y is absorbance unit.
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