Figure 8: Plot of the average charge state (z) against molecular mass (m) for various proteins that follow CRM. [(•) Observed highest charge state; () observed lowest charge state; solid curve corresponds to the average charge state predicted by (4)]. The molecular weights of the proteins given on the x-axis are in units of 106 Da. (Reprinted with permission from Analytica Chimica Acta [61], Copyright 2000, Elsevier).