Utilization of N-Bromosuccinimide as a Brominating Agent for the Determination of Sumatriptan Succinate in Bulk Drug and Tablets

Table 1

Comparison of the proposed and the existing visible spectrophotometric methods.

Sl. no.	Reagent/s	Methodology	𝜆max, nm	Beer’s law range µg mL^−1; (ε in L mol^−1 cm^−1)	Remarks	Reference
1	(a) Brucine-sodium metaperiodate	Oxidative coupling product was measured	520	4.0–20.0; NA	Less sensitive, multistep reaction	[28]
	(b) Citric acid-acetic anhydride		580	8.0–24.0; NA
2	Sodium nitroprusside acetaldehyde	Inner molecular complex formed was measured	552	4.0–20.0; (1.10 × 10^4)	Less sensitive, requires rigid pH control	[29]
3	Cobalt thiocyanate	Extracted ternary complex formed by reaction with drug was measured	629.4	16.0–48.0; (3.97 × 10^3)	Less sensitive, involves extraction step	[30]
4	Tropaeolin-OOO	Extracted ion-pair complex was measured	482.5	2.0–10.0; (2.08 × 10^4)	Requires rigid pH control; involves liquid-liquid extraction; use of organic solvents	[31]
5	(a) Chloranil in 1,4-dioxane	CT-complex measured	548	5.0–25.0; (1.00 × 10^4)	Less sensitive, involves heating step, time consuming	[32]
	(b) Chloranil and acetaldehyde		660	20.0–60.0; (3.19 × 10^4)
6	p-Chloranilic acid	CT-complex measured	520	9.28 × 10^2; 20–184	Less sensitive; use of organic solvents	[33]
7	Folin reagent	Chromogen formed by reaction with drug was measured	455.6	16.0–48.0; (3.85 × 10^3)	Less sensitive, strict pH control, time consuming	[34]
8	Folin-Ciocaltaeu reagent	Reduced FC-reagent was measured	760	2.0–6.0; NA	Narrow linear range, less sensitive	[35]
9	Bromate-bromide-
	(a) Methyl orange	Unreacted bromine was measured	508	0.2–1.6; (1.90 × 10^5)	Narrow linear range, multistep reaction, time consuming	[36]
	(b) Indigo carmine		610	2.0–12.0; (2.71 × 10^4)
10	NBS				No rigorous control of experimental conditions, no heating or extraction step, no use of organic solvents or toxic chemicals, and sensitive with wide linear dynamic range	Proposed methods
	(a) Potassium Iodide	Tri-iodide ion measured Starch-iodine complex measured	370	0.6–15.0; (𝜀=2.10×10^4)
	(b) Potassium Iodide-starch		570	0.2–4.0; (𝜀=7.44×10^4)

NBS: N-bromosuccinimide. NA: not available.