Utilization of N-Bromosuccinimide as a Brominating Agent for the Determination of Sumatriptan Succinate in Bulk Drug and Tablets
Table 2
Regression and analytical parameters.
Parameter
Method B
Method C
, nm
370
570
Beer’s law limits, µg mL−1
0.0–15.0
0.0–4.0
Molar absorptivity (ɛ), L mol−1 cm−1
2.10 × 104
7.44 × 104
Sandell sensitivitya, µg cm−2
0.0197
0.0056
Limit of detection (LOD), µg mL−1
0.34
0.07
Limit of quantification (LOQ), µg mL−1
1.02
0.20
Regression equation,
Intercept ()
0.79
0.80
Slope ()
−0.049
−0.19
Correlation coefficient ()
0.9996
0.9997
Standard deviation of intercept ()
0.074
0.078
Standard deviation of slope ()
0.009
0.037
Limit of determination as the weight in μg per mL of solution, which corresponds to an absorbance of measured in a cuvette of cross-sectional area 1 cm2 and = 1 cm.
b, where is the absorbance, is concentration in μg mL−1, is intercept, and is slope.
