Utilization of N-Bromosuccinimide as a Brominating Agent for the Determination of Sumatriptan Succinate in Bulk Drug and Tablets
Table 4
Robustness and ruggedness.
Method A
Method B
Method C
STS studied mg
Robustness (RSD, %) Volume of HCla ()
Ruggedness (RSD, %) Interburettes ()
STS studied µg mL−1
Robustness (RSD, %) Conditions altered
Ruggedness (RSD, %)
STS studied µg mL−1
Robustness (RSD, %) Conditions altered
Ruggedness (RSD, %)
Volume of HCla ()
Reaction timeb ()
Intercuvettes ()
Volume of HCla ()
Reaction timeb ()
Intercuvettes ()
4.00
0.77
1.15
6.00
1.70
1.95
2.27
1.00
1.39
1.51
1.93
6.00
1.01
0.89
9.00
2.12
1.72
2.15
2.00
1.86
1.83
2.08
8.00
0.93
1.00
12.0
1.37
1.44
1.97
3.00
1.40
1.28
1.89
In method A, volumes of 2 M HCl varied were 5 ± 1 mL; in both methods B and C, 2 M HCl (1 mL ± 0.1 mL).
bIn both methods B and C, the reaction time employed was 15 ± 1 min.