Determination of Acid Dissociation Constants (pK_𝑎) of Bicyclic Thiohydantoin-Pyrrolidine Compounds in 20% Ethanol-Water Hydroorganic Solvent

Figure 2

Potentiometric titration curves (a) and distribution curves of ligands ((b) 2a (c) 2b (d) 2c (e) 2d (f) 2e (g) 2f (h) 2g) (20% (v/v) ethanol-water mixed, 25.0±0.1°C, 𝐼=0.1 mol/L by NaCl).

(a)

(b)

(c)

(d)

(e)

(f)

(g)

(h)