Research Article

Quantification of Niacin and Its Metabolite Nicotinuric Acid in Human Plasma by LC-MS/MS: Application to a Clinical Trial of a Fixed Dose Combination Tablet of Niacin Extended-Release/Simvastatin (500 mg/10 mg) in Healthy Chinese Volunteers

Figure 2

Representative MRM chromatograms for NA (I), NUA (II), and IS 5-FU (III) in human plasma: (a) blank plasma sample; (b) blank plasma sample spiked with NA and NUA at the lowest limit of quantification (5 ng/mL) and IS (1000 ng/mL); (c) plasma sample obtained from a subject 12 h after oral administration of 3 tablets of Niacin extended-release/Simvastatin.
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