Optimization of Ultrasound-Assisted Extraction of Morphine from Capsules of Papaver somniferum by Response Surface Methodology

Table 3

Box-Behnken design of the independent variables (, , , ) and experimental results for the EY.

Number	solvent/solid ratio	pH	time	temperature	EY of morphine^*
	mL/500 mg	pH	min	°C	mg/500 mg poppy straw
1	10 mL/500 mg	1	45	40	2.40
2	20 mL/500 mg	1	45	40	3.32
3	10 mL/500 mg	13	45	40	3.12
4	20 mL/500 mg	13	45	40	3.28
5	15 mL/500 mg	7	30	30	2.25
6	15 mL/500 mg	7	60	30	2.28
7	15 mL/500 mg	7	30	50	1.80
8	15 mL/500 mg	7	60	50	2.30
9	10 mL/500 mg	7	45	30	2.26
10	20 mL/500 mg	7	45	30	2.32
11	10 mL/500 mg	7	45	50	1.50
12	20 mL/500 mg	7	45	50	2.12
13	15 mL/500 mg	1	30	40	2.90
14	15 mL/500 mg	13	30	40	3.35
15	15 mL/500 mg	1	60	40	2.97
16	15 mL/500 mg	13	60	40	3.00
17	10 mL/500 mg	7	30	40	2.12
18	20 mL/500 mg	7	30	40	2.54
19	10 mL/500 mg	7	60	40	2.26
20	20 mL/500 mg	7	60	40	2.40
21	15 mL/500 mg	1	45	30	2.76
22	15 mL/500 mg	13	45	30	2.88
23	15 mL/500 mg	1	45	50	2.81
24	15 mL/500 mg	13	45	50	2.99
25	15 mL/500 mg	7	45	40	2.24
26	15 mL/500 mg	7	45	40	2.31
27	15 mL/500 mg	7	45	40	2.07
28	15 mL/500 mg	7	45	40	2.21
29	15 mL/500 mg	7	45	40	2.27

Data are expressed as the mean ().