Stability-Indicating HPLC Determination of Gemcitabine in Pharmaceutical Formulations

Figure 5

Typical HPLC chromatogram of (a) gemcitabine exposed to alkaline stress (1 N NaOH, 60°C, 1 h), (b) contour plot, (c) peak purity index, and extracted UV spectra of (d) gemcitabine, (e) degraded product d-1, (f) d-2, (g) d-4, (h) d-5, and (i) theophylline.

(a)

(b)

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(d)

(e)

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(g)

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(i)