LOD: 0.012 µg/mL LOQ: 0.038 µg/mL. Linearity range: 0.038–1.5 µg/mL. Sensitive, accurate, and precise method, developed using design of experiment.
Gradient elution, narrow range of linearity, run time: 15 min. Nonstability indicating method (effect of pH and oxidation, exposure to sunlight or UV light, was not studied).
LOQ: 0.02 µg/mL. Linearity range: 0.02–20 µg/mL. Sensitive method for analysis of drug in plasma and serum.
Gradient elution, run time: 17 min. Applicable only for serum and plasma samples. Effect of pH, oxidation, or light on stability of raw material/formulation is not studied.
LOQ: 0.25. Linearity range: 0.25–2 ng/mL. Sensitive, simple method applicable for detection of several drugs.
Lower accuracy (85–110%) and precision (15%). Applicable for bioequivalence and pharmacokinetic studies where 15% precision is permitted. Gradient elution, run time: 21 min.
LOD: 0.15 µg/mL. Linearity ranges from 0.5 to 50 µg/mL. Isocratic, economical (less organic waste), efficient stability indicating method. Capable of separating different hydrolytic and oxidative products of drug which can be estimated separately. Symmetrical peak shape.
Degraded products are separated but not quantized.