Simultaneous Determination of Bergapten, Imperatorin, Notopterol, and Isoimperatorin in Rat Plasma by High Performance Liquid Chromatography with Fluorescence Detection and Its Application to Pharmacokinetic and Excretion Study after Oral Administration of Notopterygium incisum Extract

Table 5

Pharmacokinetic parameters of four coumarins after oral administration of N. incisum extract (, mean ± SD).

Parameters	Bergapten	Imperatorin	Notopterol	Isoimperatorin
(ng mL^−1)	183.5 ± 171.4	1667 ± 1505	23.31 ± 6.87	145.1 ± 75.9
(h)	3.06 ± 3.71	1.65 ± 1.80	0.45 ± 0.35	1.59 ± 0.97
(h)	12.8 ± 22.2	4.99 ± 3.02	3.18 ± 3.44	5.62 ± 4.06
(ng/mL h)	1638 ± 2490	10975 ± 11955	101.6 ± 34.8	830.5 ± 762.4
(ng/mL h)	1958 ± 2490	13948 ± 13926	296.2 ± 241.8	2123 ± 2866