LC-MS/MS Quantification of Tramadol and Gabapentin Utilizing Solid Phase Extraction

Table 4

Matrix effect results of TMD and GBP.

Blank plasma lots	TMD (ISNMF)		GBP (ISNMF)
	LQC	HQC	LQC	HQC
LOT-1	0.99	0.96	0.93	1.02
LOT-2	0.98	0.97	0.94	1.05
LOT-3	0.98	0.96	0.92	0.94
LOT-4	0.97	0.95	0.96	0.98
LOT-5	1.02	0.99	0.99	0.96
LOT-6	1.01	1.06	0.97	0.97
LOT-7 hemolytic	0.99	1.01	0.98	0.99
LOT-8 hemolytic	1.03	0.99	0.96	1.04
LOT-9 lipemic	0.98	0.94	0.96	0.94
LOT-10 lipemic	0.99	0.97	0.94	0.96
Mean	0.994	0.980	0.955	0.985
SD	0.0196	0.0350	0.0222	0.0395
%CV	2.0	3.6	2.3	4.0

ISTDNMF: internal standard normalised matrix factor.