Determination of Chlorpromazine, Haloperidol, Levomepromazine, Olanzapine, Risperidone, and Sulpiride in Human Plasma by Liquid Chromatography/Tandem Mass Spectrometry (LC-MS/MS)

<table class="fixed-width table-group" id="tab1"><tr><td><table class="table"><colgroup><col style="width:10.08em"/><col style="width:15.88em"/></colgroup><tr><td class="thead-hr" colspan="2"><hr/></td></tr><tr class="thead"><td class="align_center" colspan="2"><b>Injection</b></td></tr><tr><td class="thead-hr" colspan="2"><hr/></td></tr><tr><td class="align_left">Injection volume</td><td class="align_center">20 <i>μ</i>l</td></tr><tr><td class="align_left" colspan="2"><hr/></td></tr><tr><td class="align_left">Injection temperature</td><td class="align_center">40°C</td></tr><tr><td class="align_left" colspan="2"><hr/></td></tr><tr><td class="align_left">Flush volume</td><td class="align_center">250 <i>μ</i>l</td></tr><tr><td class="align_left" colspan="2"><hr/></td></tr><tr><td class="align_left">Pre-inject Flush</td><td class="align_center">2</td></tr><tr><td class="align_left" colspan="2"><hr/></td></tr><tr><td class="align_left">Post-inject Flush</td><td class="align_center">2</td></tr><tr><td class="align_left" colspan="2"><hr/></td></tr><tr><td class="align_left">Flush speed</td><td class="align_center">Medium</td></tr><tr><td class="align_left" colspan="2"><hr/></td></tr><tr><td class="align_center" colspan="2"><b>Scan</b></td></tr><tr><td class="align_left" colspan="2"><hr/></td></tr><tr><td class="align_left">Type of scan</td><td class="align_center">MRM: Multiple reaction monitoring</td></tr><tr><td class="align_left" colspan="2"><hr/></td></tr><tr><td class="align_left">Mode of scan</td><td class="align_center">Positive</td></tr><tr><td class="align_left" colspan="2"><hr/></td></tr><tr><td class="align_center" colspan="2"><b>Source/Gas parameter</b></td></tr><tr><td class="align_left" colspan="2"><hr/></td></tr><tr><td class="align_left">TEM (temperature)</td><td class="align_center">500 K</td></tr><tr><td class="align_left" colspan="2"><hr/></td></tr><tr><td class="align_left">GS1 (gas source 1)</td><td class="align_center">40 psi</td></tr><tr><td class="align_left" colspan="2"><hr/></td></tr><tr><td class="align_left">GS2 (gas source 2)</td><td class="align_center">50 psi</td></tr><tr><td class="align_left" colspan="2"><hr/></td></tr><tr><td class="align_left">CUR (curtain gas)</td><td class="align_center">10 psi</td></tr><tr><td class="align_left" colspan="2"><hr/></td></tr><tr><td class="align_left">CAD (collision gas)</td><td class="align_center">Medium</td></tr><tr><td class="align_left" colspan="2"><hr/></td></tr><tr><td class="align_left">IS (ion spray voltage)</td><td class="align_center">5,000 v</td></tr><tr><td class="align_left" colspan="2"><hr/></td></tr><tr><td class="align_left">IHE (interface heater)</td><td class="align_center">On</td></tr><tr class="table-tr"><td colspan="2"><hr class="tbody-hr"/></td></tr></table></td></tr></table>

<div>Optimal instrumental settings.</div>

International Journal of Analytical Chemistry

tab1

Table 1

Table 1: Determination of Chlorpromazine, Haloperidol, Levomepromazine, Olanzapine, Risperidone, and Sulpiride in Human Plasma by Liquid Chromatography/Tandem Mass Spectrometry (LC-MS/MS) 

Table 1 | Determination of Chlorpromazine, Haloperidol, Levomepromazine, Olanzapine, Risperidone, and Sulpiride in Human Plasma by Liquid Chromatography/Tandem Mass Spectrometry (LC-MS/MS) 