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International Journal of Analytical Chemistry
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International Journal of Analytical Chemistry
/
2018
/
Article
/
Tab 4
/
Research Article
Determination of Chlorpromazine, Haloperidol, Levomepromazine, Olanzapine, Risperidone, and Sulpiride in Human Plasma by Liquid Chromatography/Tandem Mass Spectrometry (LC-MS/MS)
Table 4
Retention times, calibration curve linearity, LOD, and LOQ.
Antipsychotics
Rt(min)
Therapeutic range (ng/ml)
Concentration range (ng/ml)
Regression equations
R
2
LOD (ng/ml)
LOQ (ng/ml)
Chlorpromazine
2.45±0.04
30-300
15-450
y = 0.06762x +
0.99965
3.95 (0.53)
13.17 (1.70
)
(15, 30, 75, 150, 300 and 450)
0.17059
Haloperidol
5.38±0.05
5-17
2-60
y = 0.18126x +
0.99902
0.36 (0.11)
1.19 (0.49
)
(2, 4, 10, 20, 40 and 60)
0.06470
Levomepromazine
5.62±0.08
15-60
5-150
y = 0.03452x +
0.99927
1.50 (0.80)
4.99 (2.26
)
(5, 10, 25, 50, 100 and 150)
0.01757
Olanzapine
2.34±0.05
20-80
5-150
y = 0.03241x -
0.99915
0.87 (0.33)
2.89 (1.01
)
(5, 10, 25, 50, 100 and 150)
0.01622
Risperidone
3.88±0.05
20-60
5-150
y = 0.08304x +
0.99975
1.378 (0.15)
4.59 (0.52
)
(5, 10, 25, 50, 100 and 150)
0.01389
Sulpiride
5.07±0.05
200-1,000
40-1,200
y = 0.04711x +
0.99984
2.11 (0.41)
7.04 (1.82
)
(40, 80, 200, 400, 800 and 1,200)
0.05818
(
): LOD and LOQ using S/N approach.