Determination of Chlorpromazine, Haloperidol, Levomepromazine, Olanzapine, Risperidone, and Sulpiride in Human Plasma by Liquid Chromatography/Tandem Mass Spectrometry (LC-MS/MS)

Table 5

Precision and accuracy values.

Antipsychotics	Concentration level (ng/ml)	Precision (CV)		Accuracy (relative bias)
		Intraday assay (n=5)	Interday assay; (n = 5 within 3 days)	Intraday assay (n=5)	Interday assay; (n = 5 within 3 days)
Chlorpromazine	15	7.15	1.09	5.97	-4.87
	30	7.75	9.16	9.60	-2.40
	75	4.23	1.65	-1.12	-1.21
	150	4.01	4.69	-3.93	0.48
	300	4.58	1.50	0.53	1.67
	450	4.09	0.63	0.18	-0.74
	CQ1 (13)	4.01	8.50	8.62	6.50
	CQ2 (39)	4.36	1.20	8.67	6.12
	CQ3 (160)	5.15	7.71	0.14	4.80
	CQ4 (250)	3.18	1.91	1.06	2.42
Haloperidol	2	8.58	1.10	-9.02	-5.15
	4	2.20	1.25	-3.00	-0.99
	10	3.98	1.35	-4.36	-3.53
	20	1.98	0.61	2.39	1.59
	40	3.63	0.22	2.93	1.65
	60	4.37	1.26	-1.42	-0.80
	CQ1 (1)	3.66	6.54	4.52	9.65
	CQ2 (3)	3.52	8.56	-4.69	-0.13
	CQ3 (30)	1.13	0.62	7.16	6.00
	CQ4 (45)	1.78	0.87	0.35	-0.66
Levomepromazine	5	3.35	6.10	0.78	11.92
	10	3.12	6.31	8.77	10.55
	25	2.69	2.85	-1.05	-2.18
	50	6.08	1.95	-5.12	-6.56
	100	6.88	2.86	1.85	2.50
	150	4.82	0.96	-0.27	-0.40
	CQ1 (2)	2.16	7.17	-3.57	11.01
	CQ2 (6)	3.54	9.77	9.73	11.26
	CQ3 (80)	2.41	2.14	7.82	3.01
	CQ4 (120)	3.21	1.43	0.67	-1.90
Olanzapine	5	1.56	2.22	-5.66	5.13
	10	5.79	3.47	3.19	10.40
	25	5.51	3.59	-6.41	-0.18
	50	2.80	1.12	-7.91	-5.97
	100	2.72	2.33	0.64	1.82
	150	3.15	0.79	-0.74	-0.22
	CQ1 (3)	1.79	7.25	-5.05	9.78
	CQ2 (9)	3.87	3.31	-8.60	1.54
	CQ3 (80)	5.10	1.68	-0.09	3.14
	CQ4 (120)	4.72	2.52	3.37	-1.13
Risperidone	5	7.58	2.78	6.48	2.00
	10	4.28	1.77	-0.88	-6.12
	25	5.01	4.69	-5.73	-4.09
	50	4.70	1.04	2.49	2.52
	100	2.24	0.62	0.42	1.48
	150	2.63	0.56	-0.30	-0.79
	CQ1 (5)	3.58	2.81	4.36	-1.17
	CQ2 (15)	4.36	1.17	4.54	5.04
	CQ3 (80)	1.72	0.23	-1.04	0.41
	CQ4 (120)	1.75	0.57	-2.01	0.05
Sulpiride	40	3.99	5.91	9.60	9.10
	80	1.82	1.30	7.34	7.01
	200	5.08	1.37	-4.52	-4.55
	400	3.73	2.01	-1.12	-0.34
	800	2.63	1.22	0.09	-0.10
	1,200	1.17	1.79	0.18	0.17
	CQ1 (7)	4.62	5.15	-7.46	-4.13
	CQ2 (21)	2.67	10.28	-8.20	-1.40
	CQ3 (600)	2.42	2.16	-0.54	0.13
	CQ4 (800)	2.23	0.53	0.15	-1.09