International Journal of Analytical Chemistry / 2018 / Article / Tab 5 / Research Article
Determination of Chlorpromazine, Haloperidol, Levomepromazine, Olanzapine, Risperidone, and Sulpiride in Human Plasma by Liquid Chromatography/Tandem Mass Spectrometry (LC-MS/MS) Table 5 Precision and accuracy values.
Antipsychotics Concentration level (ng/ml) Precision (CV ) Accuracy (relative bias ) Intraday assay (n=5) Interday assay (n = 5 within 3 days) Intraday assay (n=5) Interday assay (n = 5 within 3 days) Chlorpromazine 15 7.15 1.09 5.97 -4.87 30 7.75 9.16 9.60 -2.40 75 4.23 1.65 -1.12 -1.21 150 4.01 4.69 -3.93 0.48 300 4.58 1.50 0.53 1.67 450 4.09 0.63 0.18 -0.74 CQ1 (13) 4.01 8.50 8.62 6.50 CQ2 (39) 4.36 1.20 8.67 6.12 CQ3 (160) 5.15 7.71 0.14 4.80 CQ4 (250) 3.18 1.91 1.06 2.42 Haloperidol 2 8.58 1.10 -9.02 -5.15 4 2.20 1.25 -3.00 -0.99 10 3.98 1.35 -4.36 -3.53 20 1.98 0.61 2.39 1.59 40 3.63 0.22 2.93 1.65 60 4.37 1.26 -1.42 -0.80 CQ1 (1) 3.66 6.54 4.52 9.65 CQ2 (3) 3.52 8.56 -4.69 -0.13 CQ3 (30) 1.13 0.62 7.16 6.00 CQ4 (45) 1.78 0.87 0.35 -0.66 Levomepromazine 5 3.35 6.10 0.78 11.92 10 3.12 6.31 8.77 10.55 25 2.69 2.85 -1.05 -2.18 50 6.08 1.95 -5.12 -6.56 100 6.88 2.86 1.85 2.50 150 4.82 0.96 -0.27 -0.40 CQ1 (2) 2.16 7.17 -3.57 11.01 CQ2 (6) 3.54 9.77 9.73 11.26 CQ3 (80) 2.41 2.14 7.82 3.01 CQ4 (120) 3.21 1.43 0.67 -1.90 Olanzapine 5 1.56 2.22 -5.66 5.13 10 5.79 3.47 3.19 10.40 25 5.51 3.59 -6.41 -0.18 50 2.80 1.12 -7.91 -5.97 100 2.72 2.33 0.64 1.82 150 3.15 0.79 -0.74 -0.22 CQ1 (3) 1.79 7.25 -5.05 9.78 CQ2 (9) 3.87 3.31 -8.60 1.54 CQ3 (80) 5.10 1.68 -0.09 3.14 CQ4 (120) 4.72 2.52 3.37 -1.13 Risperidone 5 7.58 2.78 6.48 2.00 10 4.28 1.77 -0.88 -6.12 25 5.01 4.69 -5.73 -4.09 50 4.70 1.04 2.49 2.52 100 2.24 0.62 0.42 1.48 150 2.63 0.56 -0.30 -0.79 CQ1 (5) 3.58 2.81 4.36 -1.17 CQ2 (15) 4.36 1.17 4.54 5.04 CQ3 (80) 1.72 0.23 -1.04 0.41 CQ4 (120) 1.75 0.57 -2.01 0.05 Sulpiride 40 3.99 5.91 9.60 9.10 80 1.82 1.30 7.34 7.01 200 5.08 1.37 -4.52 -4.55 400 3.73 2.01 -1.12 -0.34 800 2.63 1.22 0.09 -0.10 1,200 1.17 1.79 0.18 0.17 CQ1 (7) 4.62 5.15 -7.46 -4.13 CQ2 (21) 2.67 10.28 -8.20 -1.40 CQ3 (600) 2.42 2.16 -0.54 0.13 CQ4 (800) 2.23 0.53 0.15 -1.09