Determination of Chlorpromazine, Haloperidol, Levomepromazine, Olanzapine, Risperidone, and Sulpiride in Human Plasma by Liquid Chromatography/Tandem Mass Spectrometry (LC-MS/MS)

Table 6

Recovery, concentration range, LOD, and LOQ from different mass spectrometry methods.

Antipsychotics	Extraction recovery ()	Concentration range (ng/ml)	LOD (ng/ml)	LOQ (ng/ml)
Chlorpromazine	67 [10]	30- 300 [10]	11.3 [24]	15 [24]
	84.5 [28]	15-600 [28]	7.5 [28]	15 [28]
	94.13 [32]	10-1,000 [30]	0.3 [32]	1 [29]
		1-50 [32]		1 [32]
Haloperidol	65 [10]	5-17 [10]	3.8 [24]	5 [24]
	93.97 [23]	1-60 [26]	<0.5 [27]	1 [26]
	86.95 [12]	2.5-30 [28]	1 [28]	1 [27]
	88.5 [33]	1-20 [30]	0.3 [32]	2.5 [28]
	83 [28]	1-50 [32]		0.5 [29]
				0.23 [30]
				1 [32]
Levomepromazine	70 [10]	15-60 [10]	5 [28]	7.5 [24]
	81 [28]	10-300 [28]		10 [28]
		10-1,000 [30]		0.47 [30]
Olanzapine	92.02 [23]	2-200 [25]	1 [27]	2 [25]
	96 [25]	10-160 [28]	2 [28]	5 [27]
	93.95 [12]	10-1,000 [30]		10 [28]
	102 [33]			0.5 [29]
	77 [28]			1.83 [30]
	86 [31]
Risperidone	69 [10]	5- 60 [10]	1.9 [24]	2.5 [24]
	89.6 [23]	1.5-60 [28]	<1 [27]	5 [27]
	94 [25]	1-50 [30]	0.8 [28]	1.5 [28]
	88.85 [12]			0.67 [30]
	84 [33]
	80.5 [28]
	88.5 [31]
Sulpiride	12 [10]	200-1,000 [10]	75 [24]	100 [24]
	105 [28]	100-1,500 [28]	2 [27]	20 [27]
		100-10,000 [30]	80 [28]	100 [28]
				8.3 [30]

Sample volume (l): 50 [10], 200 [12], 250 [23], 500 [24], 200 [25], 100 [26], 500 [27], 500 [28], 200 [29], 100 [30], 250 [31], 200 [32], and 500 [33].
Sample preparation technique: LLE [10, 12, 23–26, 28, 30, 31, 33]; SPE [27, 29, 32].