Determination of Chlorpromazine, Haloperidol, Levomepromazine, Olanzapine, Risperidone, and Sulpiride in Human Plasma by Liquid Chromatography/Tandem Mass Spectrometry (LC-MS/MS)

Table 7

Evaluation of sample storage procedure.

Antipsychotics	Nominal concentrations of QC (ng/ml)	Stability: Storage condition of samples
Chlorpromazine	13	Four freeze/thaw cycles
	39	Bench top (6 h)
	160	Autosampler stability (24 h)
	250	Preserved during 1 month at -20°C
Haloperidol	1	Three freeze/thaw cycles
	3	Bench top (6 h)
	30	Autosampler stability (12 h)
	45	Preserved during 1 month at -20°C
Levomepromazine	2	Four freeze/thaw cycles
	6	Bench top (6 h)
	80	Autosampler stability (24 h)
	120	Preserved during 1 month at -20°C
Olanzapine	3	Four freeze/thaw cycles
	9	Bench top (6 h)
	80	Autosampler stability (24 h)
	120	Preserved during 1 month at -20°C
Risperidone	5	Three freeze/thaw cycles
	15	Bench top (6 h)
	80	Autosampler stability (24 h)
	120	Preserved during 1 month at -20°C
Sulpiride	7	Four freeze/thaw cycles
	21	Bench top (6 h)
	600	Autosampler stability (24 h)
	800	Preserved during 1 month at -20°C