Comprehensive Assessment of Degradation Behavior of Simvastatin by UHPLC/MS Method, Employing Experimental Design Methodology

Figure 6

Optimization of the selected responses by means of the desirability function. The red area corresponds to the optimum conditions while time maintained constant: (a) acid degradation; (b) alkali degradation; (c) oxidative degradation; and (d) thermal degradation.

(a)

(b)

(c)

(d)