Comprehensive Assessment of Degradation Behavior of Simvastatin by UHPLC/MS Method, Employing Experimental Design Methodology

Table 7

Comparison of experimental and predictive values of different responses under optimal conditions.

Parameters	Predicted (%)		Obtained (%)		Predicted Error
	Total; imp.	RRT; 1.16	Total; imp.	RRT; 1.16	Total; imp.	RRT; 1.16
Acid degradation	18.25	0.06	18.47	0.065	1.21	8.63
Alkali degradation	14.65	0.16	14.24	0.19	2.88	-15.78
Oxidative degradation	5.36	0.19	5.68	0.19	2.53	NA
Thermal degradation	5.18	0.05	4.88	BDL	-5.24	NA

Predicted error = (obtained values – predicted)/predicted 100 BDL (below disregard limit) (0.05%); NA: not applicable.