Application of the Principles of Green Chemistry for the Development of a New and Sensitive Method for Analysis of Ertapenem Sodium by Capillary Electrophoresis

Table 8

Factors evaluated in the experimental model of Plackett-Burman.

Analytical Parameter

Factorial Combination

1

2

3

4

5

6

7

8

9

10

11

12

13

14

15

(A) Buffer Concentration

11 mM

11 mM

11 mM

10 mM

11 mM

10 mM

10 mM

10 mM

9 mM

9 mM

9 mM

10 mM

9 mM

10 mM

10 mM

(B) Voltage

15 kV

16 kV

16 kV

16 kV

15 kV

16 kV

15 kV

15 kV

15 kV

14 kV

14 kV

14 kV

15 kV

14 kV

15 kV

(C) Wavelength

214 nm

214 nm

215 nm

215 nm

215 nm

214 nm

215 nm

214 nm

214 nm

214 nm

213 nm

213 nm

213 nm

214 nm

213 nm

(D) Injection Time

6 s

5 s

5 s

6 s

6 s

6 s

5 s

5 s

4 s

5 s

5 s

4 s

4 s

4 s

5 s

(E) Rinsing of capillary

2 min

3 min

2 min

2 min

3 min

3 min

3 min

2 min

2 min

1 min

2 min

2 min

1 min

1 min

1 min

(F) Temperature of cartridge

26°C

25°C

26°C

25°C

25°C

26°C

26°C

25°C

24°C

25°C

24°C

25°C

25°C

24°C

24°C

(G) Temperature of sample storage

26°C

26°C

25°C

26°C

25°C

25°C

26°C

25°C

24°C

24°C

25°C

24°C

25°C

25°C

24°C