Simultaneous Determination of Schisandrin and Promethazine with Its Metabolite in Rat Plasma by HPLC-MS/MS and Its Application to a Pharmacokinetic Study

Figure 3

HPLC-MS/MS MRM chromatograms of (a) blank plasma, (b) spiked plasma with IS, (c) spiked blank plasma with PMZ, PMZSO, schisandrin, and IS samples, and (d) actual rat plasma samples collected at 1 h after oral administration. 1: metronidazole; 2: PMZSO; 3: PMZ; 4: schisandrin; 5: bifendate.

(a)

(b)

(c)

(d)