Simultaneous Determination of Schisandrin and Promethazine with Its Metabolite in Rat Plasma by HPLC-MS/MS and Its Application to a Pharmacokinetic Study

Table 1

MRM transitions, retention time, and conditions of analytes and internal standards.

Compound	Retention time (min)	Precursor ion	Product ion	Fragmentor (V)	Collision energy	Cell accelerator voltage
Promethazine	5.62	285.1	86.1	95	13	8
Promethazine sulfoxide	3.15	301.2	86.1	125	25	8
Metronidazole	1.47	172.1	128.1	100	10	5
Schisandrin	9.77	433.2	384.2	90	16	6
Bifendate	11.03	387.1	328	135	10	7