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International Journal of Analytical Chemistry
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International Journal of Analytical Chemistry
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2019
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Article
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Tab 3
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Research Article
Simultaneous Determination of Schisandrin and Promethazine with Its Metabolite in Rat Plasma by HPLC-MS/MS and Its Application to a Pharmacokinetic Study
Table 3
Intra- and interday precision (RSD, %) and accuracy (bias, %) of QC samples.
Compound
Nominal concentration (ng/mL)
Intraday
Interday
Observed concentration (ng/mL)
RSD (%)
Bias (%)
Observed concentration (ng/mL)
RSD (%)
Bias (%)
Promethazine
0.5
0.52
12.57
4.56
0.50
16.97
1.01
1.25
1.19
8.91
−4.02
1.17
11.22
−5.61
12.5
11.79
6.56
−5.60
11.79
9.24
−5.61
150
137.95
10.47
−8.02
140.96
13.31
−6.02
Promethazine sulfoxide
0.5
0.52
6.84
5.63
0.54
6.24
9.44
1.25
1.26
1.37
1.23
1.28
6.10
2.56
12.5
13.92
5.09
11.40
13.84
5.10
10.74
150
138.65
3.54
−7.56
137.21
8.18
−8.52
Schisandrin
0.5
0.53
5.37
6.49
0.49
12.56
−1.95
1.25
1.29
9.44
3.88
1.28
6.07
2.51
12.5
13.09
6.15
4.75
13.17
6.25
5.43
150
156.50
5.32
4.33
156.69
6.39
4.46