Simultaneous Determination of Schisandrin and Promethazine with Its Metabolite in Rat Plasma by HPLC-MS/MS and Its Application to a Pharmacokinetic Study

Table 6

Pharmacokinetic parameters of PMZ and PMZSO in rats after oral administration of PMZ with or without S. chinensis (n = 6-7).

Compound	Group	AUC (0-t) (ng h/mL)	t1/2 (h)	Tmax (h)	Cmax (ng/mL)
Promethazine	Promethazine	37.53 ± 9.54	5.92 ± 3.84	0.36 ± 0.13	14.35 ± 6.17
	PMZ + WWZ	42.72 ± 12.96	6.55 ± 3.16	6.11 ± 3.45	6.96 ± 2.12
	PMZ + WWZ for 3 weeks	24.76 ± 3.45	3.47 ± 0.97	5.67 ± 0.82	3.59 ± 0.57
Promethazine sulfoxide	Promethazine	179.33 ± 56.01	3.35 ± 1.33	3.43 ± 1.51	23.37 ± 5.33
	PMZ + WWZ	177.52 ± 30.35	2.55 ± 0.41	5.67 ± 1.51	25.58 ± 9.24
	PMZ + WWZ for 3 weeks	156.14 ± 26.04	2.72 ± 0.59	4.00 ± 1.15	23.86 ± 3.47

indicates significant differences from the PMZ group.