Table of Contents Author Guidelines Submit a Manuscript
International Journal of Analytical Chemistry
Volume 2019, Article ID 5628160, 12 pages
https://doi.org/10.1155/2019/5628160
Research Article

Simultaneous Determination of Seven Active Components in Rat Plasma by UHPLC-MS/MS and Application to a Quantitative Study after Oral Administration of Huang-Lian Jie-Du Decoction in High Fat-Induced Atherosclerosis Rats

1Jiangxi Provincial Key Laboratory of TCM Etiopathogenesis, Jiangxi University of Traditional Chinese Medicine, Nanchang 330004, China
2Key Laboratory of Pharmacology of Traditional Chinese Medicine in Jiangxi, Nanchang 330004, China
3Pharmacy Department of Zhejiang Hospital, Hangzhou 310013, China
4Center for Health System and Policy Research, Institute of Medical Information, Chinese Academy of Medical Sciences, Beijing 100020, China

Correspondence should be addressed to Guoliang Xu; moc.621@6066gnailougux

Received 13 April 2019; Revised 23 May 2019; Accepted 10 June 2019; Published 1 July 2019

Academic Editor: Samuel Carda-Broch

Copyright © 2019 Li Jiang et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. L. G. Spagnoli, E. Bonanno, G. Sangiorgi, and A. Mauriello, “Role of inflammation in atherosclerosis,” Journal of Nuclear Medicine, vol. 48, no. 11, pp. 1800–1815, 2007. View at Publisher · View at Google Scholar
  2. C. J. Wang, J. T. Liu, F. Guo, Y. Ji, and N. Liu, “Endothelin-1 induces the expression of C-reactive protein in rat vascular smooth muscle cells,” Biochemical & Biophysical Research Communications, vol. 389, pp. 537–542, 2009. View at Publisher · View at Google Scholar
  3. R. Ross, “Atherosclerosis--an inflammatory disease,” The New England Journal of Medicine, vol. 340, no. 2, pp. 115–126, 1999. View at Publisher · View at Google Scholar
  4. K. M. Qin, H. Guo, Z. S. Xu, Z. Q. Yao, and B. C. Cai, “Research status of chemical constituents and pharmacokinetics of huanglian jiedu tang,” Anti-Infection Pharm, vol. 8, pp. 3–7, 2011. View at Google Scholar
  5. W. P. Wang, “Effect of basic Therapy combined with Huanglian jiedu decoction on carotid Atherosclerotic plaque and inflammatory factors in patients with Coronary Heart Disease,” Chinese Journal of Integrative Medicine on Cardio/Cerebrovascular, vol. 15, pp. 3151–3153, 2017. View at Google Scholar
  6. W. J. Yang and P. Wang, “Intervention study of Huanglian jiedu decoction on obese patients with type 2 diabetes mellitus,” Shandong Journal of Traditional Chinese Medicine, vol. 32, pp. 535–537, 2013. View at Google Scholar
  7. N. Sekiya, N. Shibahara, I. Sakakibara, N. Hattori, H. Goto, and K. Terasawa, “Inhibitory effects of oren-gedoku-to (Huanglian-Jie-Du-Tang) on free radical-induced lysis of human red blood cells,” Phytotherapy Research, vol. 17, pp. 147–151, 2003. View at Publisher · View at Google Scholar
  8. R. X. Fang, Z. X. Liu, and X. H. Zhong, “Analysis of clinical effect, serum cytokines, VEGF and NO in unstable angina pectoris patients treated with Huang-Lian Jie-Du decoction combined with atorvastatin,” Pharmacology and Clinics of Chinese Materia Medica, vol. 36, pp. 229–232, 2017. View at Google Scholar
  9. Q. M. Chu, W. C. Wei, Z. Jin, and W. Wu, “Post-treatment of huanglian jiedu decoction on myocardial infarction patients with acute ST segment elevation,” in Chinese Archives of Traditional Chinese Medicine, vol. 36, pp. 823–826, 2018. View at Google Scholar
  10. Y. Xu, M. Qin, Y. K. Zhao, and Y. Liu, “The effect of cholesterol lowing and anti-atherosclerosis of hanglian jiedu tang and its components,” Chinese Journal of Experimental Traditional Medical Formulae, vol. 14, pp. 74–77, 2008. View at Google Scholar
  11. J.-M. Brusq, N. Ancellin, P. Grondin et al., “Inhibition of lipid synthesis through activation of AMP kinase: an additional mechanism for the hypolipidemic effects of berberine,” Journal of Lipid Research, vol. 47, no. 6, pp. 1281–1288, 2006. View at Publisher · View at Google Scholar · View at Scopus
  12. O. S. Kim, C.-S. Seo, Y. Kim, H.-K. Shin, and H. Ha, “Extracts of scutellariae radix inhibit low-density lipoprotein oxidation and the lipopolysaccharide-induced macrophage inflammatory response,” Molecular Medicine Reports, vol. 12, no. 1, pp. 1335–1341, 2015. View at Publisher · View at Google Scholar · View at Scopus
  13. I.-A. Lee, J. H. Lee, N.-I. Baek, and D.-H. Kim, “Antihyperlipidemic effect of crocin isolated from the fructus of Gardenia jasminoides and its metabolite crocetin,” Biological & Pharmaceutical Bulletin, vol. 28, no. 11, pp. 2106–2110, 2005. View at Publisher · View at Google Scholar · View at Scopus
  14. Y. Deng, T. Lu, L. Xie, and X. Liu, “High-performance liquid chromatographic method for the determination and pharmacokinetic study of wogonoside in rat serum after oral administration of traditional Chinese medicinal preparation Huang-Lian-Jie-Du decoction,” Biomedical Chromatography, vol. 20, no. 10, pp. 1098–1102, 2006. View at Publisher · View at Google Scholar
  15. T. Lu, Y. Liang, J. Song, L. Xie, G. J. Wang, and X. D. Liu, “Simultaneous determination of berberine and palmatine in rat plasma by HPLC-ESI-MS after oral administration of traditional Chinese medicinal preparation Huang-Lian-Jie-Du decoction and the pharmacokinetic application of the method,” Journal of Pharmaceutical and Biomedical Analysis, vol. 40, no. 5, pp. 1218–1224, 2006. View at Publisher · View at Google Scholar · View at Scopus
  16. H. Zhu, Z. Qian, H. Li et al., “Integrated pharmacokinetics of major bioactive components in MCAO rats after oral administration of Huang-Lian-Jie-Du-Tang,” Journal of Ethnopharmacology, vol. 141, no. 1, pp. 158–169, 2012. View at Publisher · View at Google Scholar
  17. L. B. Yu, Y. Chen, G. L. Xu et al., “Study on mechanism of huang-lian jie-du decoction on atherosclerosis rats based on anti-inflammatory and antioxidant,” Modernization of Traditional Chinese Medicine and Mateia Medica-World Science and Technology, vol. 19, pp. 1841–1845, 2017. View at Google Scholar
  18. L. B. Yu, G. L. Xu, R. Yao, J. L. Hu, J. N. Duan, and L. Jiang, “Effect of huanglian jiedu decoction on atherosclerosis rats based on blood gas analysis,” Lishizhen Medicine and Materia Medica Research, vol. 28, pp. 818–821, 2017. View at Google Scholar
  19. S. Wu, A. Sun, and R. Liu, “Separation and purification of baicalin and wogonoside from the Chinese medicinal plant Scutellaria baicalensis Georgi by high-speed counter-current chromatography,” Journal of Chromatography A, vol. 1066, no. 1-2, pp. 243–247, 2005. View at Publisher · View at Google Scholar
  20. K. Yu, Y. F. Gong, Z. Y. Lin, and Y. Y. Cheng, “Quantitative analysis and chromatographic fingerprinting for the quality evaluation of Scutellaria baicalensis Georgi using capillary electrophoresis,” Journal of Pharmaceutical and Biomedical Analysis, vol. 43, pp. 540–548, 2007. View at Publisher · View at Google Scholar
  21. J. H. Chen, F. M. Wang, J. Liu, S. C. Lee, X. R. Wang, and H. H. Yang, “Analysis of alkaloids in Coptis chinensis Franch by accelerated solvent extraction combined with ultra performance liquid chromatographic analysis with photodiode array and tandem mass spectrometry detections,” Analytica Chimica Acta, vol. 613, pp. 184–195, 2008. View at Publisher · View at Google Scholar
  22. S. Pfister, P. Meyer, A. Steck, and H. Pfander, “Isolation and structure elucidation of carotenoid-glycosyl esters in gardenia fruits (Gardenia jasminoides Ellis) and saffron (Crocus sativus Linne),” Journal of Agricultural and Food Chemistry, vol. 44, no. 9, pp. 2612–2615, 1996. View at Publisher · View at Google Scholar · View at Scopus
  23. J. Sun, J. S. Ma, J. Jin et al., “Qualitative and quantitative determination of the main components of huanglianjiedu decoction by HPLC-UV/MS,” Acta Pharmaceutica Sinica B, vol. 41, pp. 380–384, 2006. View at Google Scholar
  24. S.-K. Ku and J.-S. Bae, “Baicalin, baicalein and wogonin inhibits high glucose-induced vascular inflammation in vitro and in vivo,” BMB Reports, vol. 48, no. 9, pp. 519–524, 2015. View at Publisher · View at Google Scholar · View at Scopus
  25. Y.-Z. Yang, Y.-Z. Tang, and Y.-H. Liu, “Wogonoside displays anti-inflammatory effects through modulating inflammatory mediator expression using RAW264.7 cells,” Journal of Ethnopharmacology, vol. 148, no. 1, pp. 271–276, 2013. View at Publisher · View at Google Scholar · View at Scopus
  26. S. Lee, Y. Jeong, M. H. Yu et al., “Wogonin suppresses TNF-α-induced MMP-9 expression by blocking the NF-κB activation via MAPK signaling pathways in human aortic smooth muscle cells,” Biochemical and Biophysical Research Communications, vol. 351, no. 1, pp. 118–125, 2006. View at Publisher · View at Google Scholar
  27. Y. Shi, J. Hu, J. Geng et al., “Berberine treatment reduces atherosclerosis by mediating gut microbiota in apoE-/- mice,” Biomedicine & Pharmacotherapy, vol. 107, pp. 1556–1563, 2018. View at Publisher · View at Google Scholar
  28. N. Ning, K. He, Y. Wang et al., “Hypolipidemic effect and mechanism of palmatine from Coptis chinensis in hamsters fed high-fat diet,” Phytotherapy Research, vol. 29, pp. 668–673, 2015. View at Publisher · View at Google Scholar
  29. B. Yan, D. Wang, S. Dong et al., “Palmatine inhibits TRIF-dependent NF-κB pathway against inflammation induced by LPS in goat endometrial epithelial cells,” International Immunopharmacology, vol. 45, pp. 194–200, 2017. View at Publisher · View at Google Scholar
  30. M. Feng, Study on the Role and Mechanisms of Alkaloids of Rhizoma Coptidis and Its Derivative on Atherosclerosis, Southwest University, 2017.
  31. Y. Yang, H. J. Wang, J. Yang et al., “Chemical profiling and quantification of Chinese medicinal formula Huang-Lian-Jie-Du decoction, a systematic quality control strategy using ultra high performance liquid chromatography combined with hybrid quadrupole-orbitrap and triple quadrupole mass spectrometers,” Journal of Chromatography A, vol. 1321, pp. 88–99, 2013. View at Publisher · View at Google Scholar
  32. K.-Y. Kwok, J. Xu, H.-M. Ho et al., “Quality evaluation of commercial Huang-Lian-Jie-Du-Tang based on simultaneous determination of fourteen major chemical constituents using high performance liquid chromatography,” Journal of Pharmaceutical and Biomedical Analysis, vol. 85, pp. 239–244, 2013. View at Publisher · View at Google Scholar · View at Scopus
  33. Y. X. Deng, T. Lu, L. Xie, and X. D. Liu, “High-performance liquid chromatographic method for the determination and pharmacokinetic study of wogonoside in rat serum after oral administration of traditional Chinese medicinal preparation Huang-Lian-Jie-Du decoction,” Biomed Chromatogr, vol. 20, pp. 1098–1102, 2006. View at Publisher · View at Google Scholar
  34. M.-Y. He, Y.-X. Deng, Q.-Z. Shi, X.-J. Zhang, and Y. Lv, “Comparative pharmacokinetic investigation on baicalin and wogonoside in type 2 diabetic and normal rats after oral administration of traditional Chinese medicine Huanglian Jiedu decoction,” Journal of Ethnopharmacology, vol. 155, no. 1, pp. 334–342, 2014. View at Publisher · View at Google Scholar · View at Scopus
  35. M.-F. Zeng, L.-M. Pan, H.-X. Zhu, Q.-C. Zhang, and L.-W. Guo, “Comparative pharmacokinetics of baicalin in plasma after oral administration of Huang-Lian-Jie-Du-Tang or pure baicalin in MCAO and sham-operated rats,” Fitoterapia, vol. 81, no. 6, pp. 490–496, 2010. View at Publisher · View at Google Scholar · View at Scopus
  36. H. Zhu, Z. Qian, F. He et al., “Novel pharmacokinetic studies of the Chinese formula Huang-Lian-Jie-Du-Tang in MCAO rats,” Phytomedicine, vol. 20, no. 10, pp. 767–774, 2013. View at Publisher · View at Google Scholar
  37. The State Pharmacopoeia Commission of P.R. China, “Methodology validation guidelines for quantitative analysis of biological samples,” in Pharmacopoeia of the People’s Republic of China, vol. IV, pp. 363–368, Chin Med Sci Press, Beijing, China, 2015 edition, 2015. View at Google Scholar
  38. X. R. Gu, S. Y. Fang, W. Ren et al., “Pharmacodynamics of Huanglian Jiedu decoction in Alzheimer's disease (AD) model rats and effect on improvement of inflammation microenvironment in brain,” China Journal of Chinese Materia Medica, vol. 43, pp. 3006–3011, 2018. View at Google Scholar
  39. F. Zuo, N. Nakamura, T. Akao, and M. Hattori, “Pharmacokinetics of berberine and its main metabolites in conventional and pseudo germ-free rats determined by liquid chromatography/ion trap mass spectrometry,” Drug Metabolism & Disposition, vol. 34, Article ID 011361, pp. 2064–2072, 2006. View at Google Scholar
  40. S. Yu, X. Pang, Y. Deng et al., “A sensitive and specific liquid chromatography mass spectrometry method for simultaneous determination of berberine, palmatine, coptisine, epiberberine and jatrorrhizine from Coptidis Rhizoma in rat plasma,” International Journal of Mass Spectrometry, vol. 268, no. 1, pp. 30–37, 2007. View at Publisher · View at Google Scholar · View at Scopus
  41. X. Tan, J. Ma, R. Feng et al., “Tissue distribution of berberine and its metabolites after oral administration in rats,” PLoS ONE, vol. 8, no. 10, p. e77969, 2013. View at Publisher · View at Google Scholar
  42. C. Zhang, R. Yu, Y. Liu et al., “Interaction of baicalin with berberine for glucose uptake in 3T3-L1 adipocytes and HepG2 hepatocytes,” Journal of Ethnopharmacology, vol. 151, no. 2, pp. 864–872, 2014. View at Publisher · View at Google Scholar
  43. L. Jiang, J. D. Dai, Z. L. Huang, Q. H. Du, J. H. Lin, and Y. R. Wang, “Simultaneous determination of gastrodin and puerarin in rat plasma by HPLC and the application to their interaction on pharmacokinetics,” Journal of Chromatography B, vol. 915–916, pp. 8–12, 2013. View at Google Scholar
  44. D. A. Chistiakov, Y. V. Bobryshev, E. Kozarov, I. A. Sobenin, and A. N. Orekhov, “Role of gut microbiota in the modulation of atherosclerosis-associated immune response,” Frontiers in Microbiology, vol. 6, p. 671, 2015. View at Publisher · View at Google Scholar