Application of Factorial and Doehlert Designs for the Optimization of the Simultaneous Separation and Determination of Antimigraine Drugs in Pharmaceutical Formulations by RP-HPLC-UV

Table 7

Method precision and accuracy for the recovery of studied compounds.

Compound	Amount spiked (μg·mL^−1)	Amount recovered (μg·mL^−1)	Mean recovery (%)	RSD (%)
At 60% level
Zol	30	29.96	97.92	0.43
Nara	30	30.19	100.56	0.93
Keto	30	29.40	97.99	0.11
DHE	30	30.22	100.73	0.69
Pizo	30	30.58	100.94	0.16
At 80% level
Zol	40	41.07	101.17	0.85
Nara	40	39.84	99.60	1.16
Keto	40	40.55	101.38	0.94
DHE	40	40.12	100.31	0.89
Pizo	40	40.28	99.95	1.54
At 100% level
Zol	50	51.39	101.57	0.83
Nara	50	50.59	101.18	0.96
Keto	50	50.89	101.78	1.55
DHE	50	49.88	99.77	2.36
Pizo	50	50.55	100.49	1.90
At 120% level
Zol	60	60.11	99.20	0.69
Nara	60	58.63	97.72	2.02
Keto	60	58.98	98.30	1.00
DHE	60	58.99	98.31	1.47
Pizo	60	58.74	97.41	0.77
At 140% level
Zol	70	70.44	99.78	0.24
Nara	70	70.77	101.11	1.42
Keto	70	70.18	100.26	0.35
DHE	70	70.79	101.12	0.50
Pizo	70	71.35	101.50	0.57