RP-HPLC Method Development and Validation of Synthesized Codrug in Combination with Indomethacin, Paracetamol, and Famotidine

Table 1

Summary of method development optimization.

Drug	Mobile phase		pH	Diluent used
	Buffer	ACN
FAM and IND mixture	93	7	6	Diluent 1
	93	7	5
	50	50	5.5
	60	40	5.5 & 6
	40	60	5.5 & 5
Codrug	40	60	5	Diluent 1
PAR	40	60	5	Diluent 1
				Methanol
				ACN
FAM, codrug, and IND separately	40	60	5	ACN
Mixture of all drugs	40	60	5	ACN