RP-HPLC Method Development and Validation of Synthesized Codrug in Combination with Indomethacin, Paracetamol, and Famotidine

Table 4

Results of the robustness at different variable parameters.

		FAM	PAR	IND	Codrug
The wavelength of maximal absorption (λmax)
273 nm	Av. area	4279022	2357627	7713100	4191009
275 nm	Av. area	4225523	2324816	7797471	4109888
277 nm	Av. area	4263527	2374482	7759887	4186203
	% RSD	0.65	1.07	0.54	1.09
Mobile pH
pH 5.1	Av. area	4353746	2280521	7609836	4089088
pH 4.9	Av. area	4355659	2247925	7803400	4177253
pH 5.0	Av. area	4225523	2324816	7797471	4109888
	% RSD	1.73	1.69	1.42	1.12
Flow rate
Flow rate of 1.2 mL/min.	Av. area	4289108	2336035	7620148	4220573
Flow rate of 1.4 mL/min.	Av. area	4225523	2324816	7797471	4109888
	% RSD	1.06	0.34	1.63	1.88