Fiberoptic-Coupled Spectrofluorometer with Array Detection as a Process Analytical Chemistry Tool for Continuous Flow Monitoring of Fluoroquinolone Antibiotics

Table 2

Comparison of this method with other reported methods for determination of fluoroquinolones.

Method	Linear range (μg·mL^−1)	Detection limit (μg·mL^−1)
Spectrofluorometric [65]	0.02–2.2	0.006–0.016
HPLC-UV [89]	0.15 to 5	0.04–0.08
HPLC [57]	0.003–1.3	0.001
HPLC-fluorescence [90]	0.005–0.1	0.0005–0.005
Capillary electrophoresis [83]	5–20	1.1 and 2.4
Chemiluminescence [77]	1.98 × 10^−9	0.003–7
HPLC–PDA [91]	0.1–10	0.03
Spectrophotometric [72]	0.5–25	0.084
HPLC [92]	0.0005–1	0.00007
This method	0.25–20	0.035–0.093