Fiberoptic-Coupled Spectrofluorometer with Array Detection as a Process Analytical Chemistry Tool for Continuous Flow Monitoring of Fluoroquinolone Antibiotics

Table 4

Determination of ciprofloxacin, ofloxacin, and levofloxacin in pharmaceutical formulations.

Analytes	Tissue	Original (mg·mL^−1)	Found (mg·mL^−1)	RSD (n = 5%)	Content (μg·mL^−1)	Added (μg·mL^−1)	Found (μg·mL^−1)	Recovery (n = 5%)
CIP	Infusion	2	1.99 ± 0.003	1.91	0.04 ± 1.99	1	0.05 ± 3.01	102 ± 3
			1.92 ± 0.036	1.34	0.03 ± 1.92	3	0.19 ± 5.01	103 ± 2
			1.96 ± 0.016	1.06	1.96 ± 0.02	5	0.09 ± 6.97	100 ± 2
CIP	Eye drop	3	2.91 ± 0.028	8.80	0.17 ± 1.94	1	0.23 ± 3.02	108 ± 4
			2.93 ± 0.054	7.96	0.16 ± 1.95	3	0.14 ± 5.03	102 ± 3
			2.98 ± 0.006	5.68	0.11 ± 1.98	5	0.08 ± 7.01	100 ± 3
CIP	Tablet	2.5	2.47 ± 0.009	7.06	0.14 ± 1.98	1	0.23 ± 2.96	98 ± 4
			2.47 ± 0.010	4.34	0.09 ± 1.97	3	0.17 ± 5.10	104 ± 5
			2.41 ± 0.03	6.71	0.13 ± 1.93	5	0.21 ± 6.89	99 ± 4
OFLX	Tablet	2	1.98 ± 0.006	7.24	0.14 ± 1.98	1	0.15 ± 2.97	98 ± 4
			1.91 ± 0.043	7.63	0.15 ± 1.91	3	0.19 ± 5.06	104 ± 5
			1.95 ± 0.022	6.24	0.12 ± 1.95	5	0.19 ± 6.98	99 ± 4
Levo	Tablet	5	5.37 ± 0.075	5.81	0.13 ± 2.15	1	0.35 ± 3.17	102 ± 4
			5.32 ± 0.064	5.35	0.11 ± 2.12	3	0.29 ± 5.21	103 ± 4
			5.17 ± 0.034	7.39	0.15 ± 2.06	5	0.12 ± 7.17	102 ± 3
Levo	Eye drop	5	5.38 ± 0.077	5.01	0.11 ± 2.15	1	0.26 ± 3.13	98 ± 4
			5.18 ± 0.036	5.83	0.12 ± 2.07	3	0.16 ± 5.11	101 ± 4
			5.23 ± 0.046	7.54	0.16 ± 2.09	5	0.17 ± 7.08	100 ± 4