Research Article
A Validated RP-HPLC Stability Method for the Estimation of Chlorthalidone and Its Process-Related Impurities in an API and Tablet Formulation
Table 3
Peak results for the spiked solution containing the chlorthalidone API and in-house process-related impurities.
| | Sample name | Area | RT | RRT | Resolution | Theoretical plates | Tailing factor | Purity angle | Purity threshold |
| | Chlorthalidone | 55150545 | 6.729 | — | 2.54 | 4240 | 1.21 | 9.786 | 1.001 | | Stage II | 938956 | 33.056 | 4.912 | 23.10 | 47507 | 1.26 | 0.183 | 1.129 | | Stage III | 727129 | 9.783 | 1.453 | 3.20 | 6770 | 1.17 | 0.180 | 1.108 |
|
|
