A Validated RP-HPLC Stability Method for the Estimation of Chlorthalidone and Its Process-Related Impurities in an API and Tablet Formulation

Table 4

Precision results.

Sr. no.	System precision	Method precision
	area	Stage II process impurity (%w/w)	Stage III process impurity (%w/w)
	chlorthalidone
1	143734	0.173	0.250
2	144067	0.168	0.251
3	144083	0.172	0.253
4	143872	0.169	0.255
5	143988	0.170	0.258
6	144079	0.171	0.256
Mean	143970.5	0.1705	0.254
SD	141.19	0.001871	0.00208
%RSD	0.098	1.02	0.8200