Development and Validation of UPLC-MS/MS Method for Determination of Enasidenib in Rat Plasma and Its Pharmacokinetic Application

<table class="table-group" id="tab1"><tr><td><table class="table"><tr><td class="thead-hr" colspan="6"><hr/></td></tr><tr class="thead"><td class="align_left" rowspan="2">Analyte</td><td class="align_center" rowspan="2">Concentration added (ng/mL)</td><td class="align_center" colspan="2">Intraday</td><td class="align_center" colspan="2">Interday</td></tr><tr class="thead"><td class="align_center">RSD (%)</td><td class="align_center">RE (%)</td><td class="align_center">RSD (%)</td><td class="align_center">RE (%)</td></tr><tr><td class="thead-hr" colspan="6"><hr/></td></tr><tr><td class="align_left" rowspan="3">Enasidenib</td><td class="align_center">2.5</td><td class="align_center">8.40</td><td class="align_center">−1.20</td><td class="align_center">5.46</td><td class="align_center">0.86</td></tr><tr><td class="align_center">200</td><td class="align_center">6.48</td><td class="align_center">−1.44</td><td class="align_center">5.38</td><td class="align_center">0.58</td></tr><tr><td class="align_center">800</td><td class="align_center">2.25</td><td class="align_center">2.34</td><td class="align_center">3.94</td><td class="align_center">−0.30</td></tr><tr class="table-tr"><td colspan="6"><hr class="tbody-hr"/></td></tr></table></td></tr></table>

<div>Precision and accuracy of enasidenib in rat plasma (<i>n</i> = 6).</div>

International Journal of Analytical Chemistry

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Table 1

Table 1: Development and Validation of UPLC-MS/MS Method for Determination of Enasidenib in Rat Plasma and Its Pharmacokinetic Application 