Development and Validation of UPLC-MS/MS Method for Determination of Enasidenib in Rat Plasma and Its Pharmacokinetic Application

<table class="table-group" id="tab4"><tr><td><table class="table"><tr><td class="thead-hr" colspan="6"><hr/></td></tr><tr class="thead"><td class="align_left" rowspan="2">Compounds</td><td class="align_center" rowspan="2">Spiked (ng/mL)</td><td class="align_center" colspan="2">Room temperature, 12 h</td><td class="align_center" colspan="2">−20°C, 3 months</td></tr><tr class="thead"><td class="align_center">RSD (%)</td><td class="align_center">RE (%)</td><td class="align_center">RSD (%)</td><td class="align_center">RE (%)</td></tr><tr><td class="thead-hr" colspan="6"><hr/></td></tr><tr><td class="align_left">Enasidenib</td><td class="align_center">1000</td><td class="align_center">2.88</td><td class="align_center">0.59</td><td class="align_center">3.66</td><td class="align_center">0.94</td></tr><tr class="table-tr"><td colspan="6"><hr class="tbody-hr"/></td></tr></table></td></tr></table>

<div>The stock solution stability of enasidenib in rat plasma (<i>n</i> = 6).</div>

International Journal of Analytical Chemistry

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Table 4

Table 4: Development and Validation of UPLC-MS/MS Method for Determination of Enasidenib in Rat Plasma and Its Pharmacokinetic Application 