International Journal of Analytical Chemistry / 2020 / Article / Tab 5

Research Article

Development and Validation of UPLC-MS/MS Method for Determination of Enasidenib in Rat Plasma and Its Pharmacokinetic Application

Table 5

Pharmacokinetic parameters of enasidenib in rats after 10 mg/kg oral administration (n = 8).

ParametersEnasidenib

t1/2 (h)7.99 ± 3.29
Tmax (h)1.57 ± 0.73
Cmax (ng/mL)456.80 ± 124.29
AUC0⟶t (ng/mL·h)4754.06 ± 1685.42
AUC0⟶∞ (ng/mL·h)4929.53 ± 1947.91
Vz/F (L/kg)24.91 ± 9.80
CLz/F (L/h)2.34 ± 1.01
MRT0⟶t (h)12.85 ± 1.50
MRT0⟶∞ (h)12.88 ± 1.06

Abbreviations: t1/2, half-life; Tmax, time of peak concentration; MRT(0⟶t), mean residence time of 0 ⟶ t time; MRT(0⟶∞), mean residence time of 0-infinity time; Cmax, peak concentration; AUC(0⟶t), area under the curve of 0 ⟶ t time; AUC(0⟶∞), area under the curve of 0 ⟶ infinity time; Vz/F, apparent volume of distribution; and CLz/F, clearance.

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