International Journal of Analytical Chemistry / 2020 / Article / Tab 3

Research Article

Establishment and Validation of a Liquid Chromatography-Tandem Mass Spectrometry Method for the Determination of Tigecycline in Critically Ill Patients

Table 3

Stability of TGC in human plasma under tested conditions.

StabilityNominal concentration (ng/mL)Stability sample concentration (ng/mL)Accuracy (%)CV (%)

Short‐term (24 h, 25°C)150168 ± 7.0112.34.2
38003753 ± 206.598.85.5

Short‐term (24 h, 4°C)150158 ± 14.7105.49.3
38003673 ± 212.096.85.8

Freeze-thaw (five cycles, −80−25°C)150150 ± 3.8100.12.5
38003993 ± 293.6105.17.4

Long‐term (130 days, −80°C)150156 ± 11.1103.87.1
38003524 ± 97.492.72.8

Autosampler (30 h, 30°C)150162 ± 10.4108.26.4
38004021 ± 269.0105.86.7

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