Development and Validation of a Hydrophilic Interaction Liquid Chromatography Tandem Mass Spectrometry Method for the Determination of Asparagine in Human Serum

Table 4

ASN concentrations in serum samples of ALL patients treated with ASNase.

No.	ASN concentration (μM)
	Before treatment	After treatment
1	45.86	<2
2	39.52	<2
3	36.83	<2
4	69.72	<2
5	59.18	<2
6	45.52	<2
7	54.12	<2
8	66.14	<2
9	52.76	<2
10	46.51	<2
11	90.32	<2
12	44.22	<2
13	66.60	<2
14	64.34	<2
15	59.80	<2
16	41.95	<2
17	52.65	<2
18	51.04	<2
19	46.83	<2
20	38.37	<2
21	46.79	42.63
22	77.35	<2
23	42.41	<2
24	53.70	<2
25	36.16	<2
26	47.85	<2
27	60.55	<2
28	41.40	<2
29	43.47	<2
30	43.55	17.60
31	79.48	23.60
32	54.62	<2
33	38.25	<2
34	39.82	<2
35	38.39	<2
36	58.06	<2
37	NA	<2
38	NA	<2
39	NA	<2
40	NA	<2
41	NA	<2
42	NA	<2
43	NA	<2
44	NA	<2
45	NA	<2
46	NA	<2
47	NA	<2
48	NA	<2
49	NA	<2

NA: serum samples were not collected before administration.