Pharmacokinetics of Lusutrombopag, a Novel Thrombopoietin Receptor Agonist, in Rats by UPLC-MS/MS

Table 2

Summary of stability of lusutrombopag and IS under various storage conditions (n = 6).

Condition	Concentration (ng/mL)		RSD (%)	Accuracy (%)
	Added	Measured
Room temperature, 24 h	4	4.04 ± 0.27	6.63	101.01
	400	454.94 ± 25.56	5.62	113.74
	1600	1705.61 ± 84.80	4.97	106.60
Freeze-thaw	4	4.53 ± 0.18	3.98	113.36
	400	421.27 ± 19.55	4.64	105.32
	1600	1702.84 ± 45.14	2.65	106.43
4°C, 6 h	4	4.17 ± 0.20	4.75	104.33
	400	440.99 ± 36.80	8.34	110.25
	1600	1626.84 ± 57.93	3.56	101.68
−20°C, 14 d	4	4.25 ± 0.29	6.77	106.19
	400	443.77 ± 53.63	12.09	110.94
	1600	1660.99 ± 33.63	2.02	103.82