An UPLC-MS/MS Method for Determination of Osimertinib in Rat Plasma: Application to Investigating the Effect of Ginsenoside Rg3 on the Pharmacokinetics of Osimertinib

Figure 4

Mean plasma concentration–time profiles of osimertinib in male rats (each point represents mean ± SD). (A) Mean plasma concentration–time profiles of osimertinib after intravenous administration at a single dose of 10 mg/kg in male rats (n = 10); (B) mean plasma concentration–time profiles of osimertinib after intravenous administration in presence of Rg3 (5 mg/kg, 7 days) in male rats (n = 6).