An UPLC-MS/MS Method for Determination of Osimertinib in Rat Plasma: Application to Investigating the Effect of Ginsenoside Rg3 on the Pharmacokinetics of Osimertinib

Table 2

Calibration standards for osimertinib in rat plasma (linear weighted 1/x², n = 6).

Analytes	Item	Nominal standards concentrations (ng/mL)								QCs (ng/mL)			R^2
		S1 (1)	S2 (5)	S3 (20)	S4 (50)	S5 (100)	S6 (200)	S7 (300)	S8 (400)	L (3)	M (30)	H (350)
Osimertinib	Mean	0.98	4.85	20.61	48.82	93.82	218.05	293.07	405.60	2.96	31.29	361.65	0.9972
	RSD (%)	5.61	6.06	9.68	3.39	5.95	6.84	0.79	3.65	8.48	1.71	4.75	0.12
	RE (%)	−2.31	−3.01	3.05	−2.36	−6.18	9.02	−2.31	1.27	−1.27	4.28	3.33