An UPLC-MS/MS Method for Determination of Osimertinib in Rat Plasma: Application to Investigating the Effect of Ginsenoside Rg3 on the Pharmacokinetics of Osimertinib

Table 4

Matrix effect and extraction recovery of osimertinib in rat plasma (n = 6).

Analytes	Spiked concentration (ng/mL)	Matrix effect		Extraction recovery
		Mean ± SD (%)	RSD (%)	Mean ± SD (%)	RSD (%)
Osimertinib	3 (QC-L)	105 ± 7	7.0	108 ± 2	1.7
	30 (QC-M)	109 ± 6	5.7	100 ± 7	7.1
	350 (QC-H)	114 ± 1	0.7	110 ± 8	7.6
IS	600	—	—	99.0 ± 7.9	8.0