An UPLC-MS/MS Method for Determination of Osimertinib in Rat Plasma: Application to Investigating the Effect of Ginsenoside Rg3 on the Pharmacokinetics of Osimertinib

Table 6

Pharmacokinetic parameters of osimertinib following oral administration (10 mg/kg) to male rats in the presence or absence of Rg3 (5 mg/kg, 7 days, i.g., n = 6 for each).

PK parameter	Osimertinib alone	Rg3 +  Osimertinib
Cmax (μg/mL)	0.317 ± 0.138	0.297 ± 0.122
Tmax (h)	3.33 ± 0.82	2.60 ± 0.55
t1/2 (h)	4.46 ± 0.94	5.08 ± 1.03
AUC0-t (h·μg/mL)	2.82 ± 1.20	2.60 ± 0.84
AUC0-∞ (h·μg/mL)	2.90 ± 1.21	2.72 ± 0.90
MRT0-t (h)	6.88 ± 0.62	7.18 ± 0.75
CL/F (L/h/kg)	19.8 ± 8.1	20.0 ± 6.2
Vz/F (L/kg)	130 ± 58	146 ± 54

Values are mean ± SD.