Determination of Crizotinib in Mouse Tissues by LC-MS/MS and Its Application to a Tissue Distribution Study

Table 2

Standard curves of crizotinib in different biological matrices.

Biological matrices	Calibration curve	Correlation coefficient (r)	Linearity range (ng/mL)	LLOQ (ng/mL)
Heart	y = 0.00669x + 0.1661	0.9910	20–8000	20
Liver	y = 0.00588x + 0.09477	0.9970	20–8000	20
Spleen	y = 0.00686x + 0.1450	0.9981	20–8000	20
Lung	y = 0.00548x + 0.06471	0.9961	20–8000	20
Kidney	y = 0.00683x + 0.09242	0.9981	20–8000	20
Stomach	y = 0.00519x + 0.3896	0.9993	20–8000	20
Large intestine	y = 0.00487x + 0.08338	0.9955	20–8000	20
Small intestine	y = 0.00425x + 0.06850	0.9944	20–8000	20
Brain	y = 0.00729x + 0.1480	0.9970	20–8000	20
Muscle	y = 0.00648x + 0.2758	0.9943	20–8000	20
Fat	y = 0.00630x + 0.1874	0.9988	20–8000	20